Alzheimer disease is the most common form of dementia, accounting for 50 to 80 percent of all dementia cases. Dementia involves memory loss and other impaired intellectual abilities, all of which interfere with everyday life. Though most people with Alzheimer disease are over 65 years, up to five percent have early-onset Alzheimer’s, which usually appears during the mid-40s or 50s.

Beta-amyloid is a peptide found in plaques in the brains of people with Alzheimer disease. For a long time, it has been thought that beta amyloid-played a causative role in the neural degeneration of the disease. This may be a mistaken belief, however, as highlighted by a recent Phase III clinical trial on the anti-amyloid drug semagacestat. Patients in this trial were expected to improve on this drug, which interferes with the production of gamma-secretase, the enzyme that produces beta-amyloid. Instead, the drug “did not slow disease progression and was associated with worsening of clinical measures of cognitions and the ability to perform activities of daily living,” according to a press release put out by the drug manufacturer, pharmaceutical giant Eli Lilly. The trial was stopped before completion.

As it turns out, beta-amyloid is an antimicrobial peptide, and is suggested to be secreted by the brain in self-defense against infectious pathogens, as David Perlmutter, M.D. stated at the Institute for Functional Medicine’s 20^th Symposium this past summer. We know beta-amyloid plaque builds up in the brain in people with Alzheimer disease, but what if its presence was a self-defense mechanism rather than the actual root cause of Alzheimer’s?

In a recent study by researchers at Mass General Institute for Neurodegenerative Disease, we may have our answer. The researchers stated, “Rather than beta-amyloid acting as a sole independent initiator of neuroinflammation, our data raise the possibility that the peptide may be part of a response mounted by the innate immune system. An absence of the peptide may result in increased vulnerability to infection.”¹

Two main pathogens are implicated as possible triggers of Alzheimer disease: Herpes simplex virus 1, the virus known for causing cold sores of the mouth, and found in about 90 percent of all adults; and Chlamydia pneumonia, the respiratory bacteria known to cause pneumonia.

In one study, the presence of anti-HSV IgM antibodies was found to be an even bigger risk factor for the development of Alzheimer disease than even the “Alzheimer’s gene” APOE4 allele.² In describing how Herpes may lead to Alzheimer’s, the researchers state, “Recurrent reactivation of HSV might act as a potent stimulus to the brain microglia, increasing the level of cytokines and initiating a positive feedback cycle that gives rise to an increasing accumulation of pathological changes.”

DNA from HSV1 and from Chlamydia pneumoniae has been found in the brains of people with Alzheimer disease.^3,4 HSV1 was found in specific areas affected by Alzheimer’s, and Chlamydia was actually cultured from brain samples taken from recently-deceased Alzheimer’s patients, indicating the virus was alive in the brain.

Chlamydia pneumonia is also known as the “heart attack” bacteria, found in the intraclavicular space/fluid between gums and teeth. The best prevention for this, incidentally, is the use of Plaquers dental floss; dental floss with a handle. When the bacterium is found, orthodontal work should be performed. People with high levels of hs C-reactive protein (a marker of inflammation in the body) are at particular risk for mouth infection with C. pneumoniae bacteria. C. pneumoniae is associated with heart disease because it is also commonly found in the soft plaques of people who die of acute heart attack.

Dr. Perlmutter recommends L-lysine and vitamin D3 supplementation, in addition to a diet high in lysine, which includes whole grains, fruits, vegetables, cheese, yoghurt and fish, and is low in tofu and other soy foods high in arginine. It is thought that activation of the virus, as with cold sore outbreaks, is a sign the virus might be active in other areas, like the brain. Preventing this may be helpful for people with Alzheimer’s.

So, why do people get infections in the first place, and why do these infections get activated? Well, lack of vitamin D, which is more common than most people realize, and uncontrolled blood sugar levels and insulin resistance, both triggered by a diet high in refined carbohydrates and sugar, are factors which affect both cellular and adaptive immunity, making us more prone to viral and bacterial infections.

It is important to note that there is much more to this story than infections. Alzheimer disease is a multifactorial “perfect storm” of triggers—usually inflammatory triggers—that interact and overlap, creating the final neurodegeneration of Alzheimer’s. Infectious triggers are just one small piece to this puzzle. For general protection against Alzheimer’s, remove sugar from the diet, reduce saturated fat intake, and incorporate vitamin D, omega-3 fish oil, pre- and probiotics, fiber and digestive enzymes. Be sure to sleep well, eliminate regularly, get plenty of exercise and be happy.

References

1. Soscia SJ, et al., “The Alzheimer’s disease-associated amyloid beta-protein is an antimicrobial peptide.” PLoS One. 2010 Mar 3;5(3):e9505.
2. Letenneur L, et al., “Seropositivity to herpes simplex virus antibodies and risk of Alzheimer’s disease: a population-based cohort study.” PLoS One. 2008;3(11):e3637.
3. Itzhaki RF and Wozniak MA, “Herpes simplex virus type 1 in Alzheimer’s disease: the enemy within.” J Alzheimers Dis. 2008 May;13(4):393-405.
4. Gerard HC, et al., “Chlamydophila (Chlamydia) pneumoniae in the Alzheimer’s brain.” FEMS Immunol Med Microbiol. 2006 Dec;48(3):355-66.

Leonard Smith, M.D.
Dr. Leonard Smith is a prominent Board-Certified, general, gastrointestinal and vascular surgeon who had a successful private practice for 25 years. In addition to his active surgery practice, he also incorporated lifestyle, diet, supplementation, exercise, detoxification, and stress management into many of the therapies he would prescribe. Many of his patients with cancer, cardiovascular disease, and other serious illnesses did so well under his treatment regimes that he began to devote most of his career to foundational health care and preventive medicine.

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Renew You Challenge

Let’s start this week off right!

Weekly challenge (I mean opportunity!) to help set you off on the right foot and in the right direction for bringing health to your week. You could even add it to your calendar.  Join us! 

Anxiety, or worry, is experienced by just about everyone at some point. Some people have anxiety disorders, which are more serious conditions, but it’s safe to say that most people experience at least occasional anxiety. That’s why a new study on omega-3s found in fish oil is so exciting. It’s the first study to look at the effects of fish oil on anxiety in a healthy population—meaning, in people who don’t already have an anxiety disorder. It’s already known that fish oil can be helpful for those people. But what about people who only experience anxiety here and there?

The researchers took a group of medical students and gave them omega-3 supplements for three months. The supplements contained 2,085 mg of EPA and 348 mg of DHA. Another group got a placebo. After three months, the group taking the fish oil showed a 20 percent reduction in anxiety scores and a 14 percent reduction in the production of the inflammatory marker interleukin-6 (IL-6) over the placebo group.

IL-6 is an inflammatory cytokine. Depression and anxiety are both known to involve the production of inflammatory cytokines. This is one of the gut-brain connections, actually, since the inflammation can originate in the gut. Omega-3s were able to reduce these inflammatory compounds, highlighting just one way they may be helping mood disorders like depression and anxiety.

This week, if you tend to get anxious about things, even if occasionally, and you’re not taking fish oil, you might want to reconsider. The studies on fish oil are hard to ignore.

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anxiety, anxious, cytokines, depression, DHA, EPA, fish oil, gut, gut-brain connections, healthy, inflammation, mood disorders, omega-3 supplements, Omega-3s, study

My assistant recently returned from the latest Institute for Functional Medicine conference in southern Florida. For those not familiar with Functional Medicine it is a personalized medicine that deals with primary prevention and underlying causes instead of symptoms for serious chronic disease. In other words, they teach Medical Doctors as well as all other specialties how to evaluate a person to get to the route of a problem or disease and treating the cause verses just treating the symptoms.

A big part of Functional Medicine includes the use of nutraceuticals in treatment.

This year’s conference centered on Mood Disorders, including depression, anxiety, and bipolar disorder as well as touching base on Alzheimer’s and Parkinson’s. Amazingly, one of the focuses of the lectures was the gut-brain connection in relation to mood disorders. More specifically, how reactions of our immune system and gut inflammation can directly affect our brain.

Remember that most of our immune system is in our gut.

Without getting too technical, the same type of cells and neurotransmitters found in our brain are also located within the digestive system. The development of an infection or inflammation anywhere in the body will set the immune system in action. Again, most of this reaction takes place first within the immune system of the digestive tract. Our immune system responds by the reaction of proteins called cytokines. These cytokines tell our body what type of reaction to have, such as swelling, stiffness, pain etc…It has now been shown that these cytokines will travel a very unique pathway and arrive at the brain, setting into motion a chemical reaction that results in the breakdown of the neurotransmitters involved in mood stability and inflammation within the brain itself.

Once this brain inflammation develops, it can remain for months even though the initial problem in the other part of our body gets resolved. This brain reaction can result in symptoms such as brain fog, memory problems, depression and anxiety. In addition, the influx of these cytokines to the brain can disrupt the lining of the brain called the blood-brain-barrier, causing what they now call “Leaky Brain” syndrome, making the brain more susceptible to other agents that do not normally pass this barrier. This is very similar indeed to what we know as Leaky Gut syndrome.

The more inflammation and irritation of the gut lining, as in Leaky Gut, will in turn send more of the cytokines to the brain, resulting in more inflammation and irritation there. In reverse, they are now seeing that healing the gut, reducing inflammation and supporting the immune system with the proper nutraceuticals can in turn reduce depression, anxiety and even reduce some symptoms associated with Alzheimer’s and Parkinson’s.

All the more reason to take precautionary measures by supporting your immune system with probiotics, as well as your vitamins and minerals. Taking a glutamine supplement such as IntestiNew will help keep your intestinal tract healthy, reduce inflammation and defer the development of leaky gut.

It is funny that years ago scientists and doctors treated the brain and mood disorders as a total separate entity from the rest of the body. It is nice to see that they now realize the brain is connected to the body, through something called the neck!

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Alzheimer's, cytokines, functional medicine conference, glutamine supplement, gut inflammation, IntestiNew, leaky brain, leaky gut, Probiotics