The gut-brain axis involves the connection of the gut to the brain. This connection goes in both directions—from the brain to the gut and from the gut to the brain. In one way, the gut-brain axis is connected by the vagus nerve—a large nerve connecting the brain to the intestines and other organs. The vagus nerve both sends messages to various organs, and also receives messages from these organs—including the gut—to send to the brain. A new study has established the vagus nerve as a main form of communication from the gut bacteria to the brain.

In an animal model, researchers were able to show that mice fed the probiotic Lactobacillus rhamnosus JB-1 showed less stress-, anxiety-, and depression-related behaviors than did mice not fed the bacteria. Further, the probiotic mice had lower levels of the stress hormone corticosterone, and they also experienced changes in the expression of receptors of the neurotransmitter GABA (gamma-aminobutyric acid) in the brain—highlighting the ability of probiotics to directly affect brain chemistry under normal conditions.

This is an early study that will need to be replicated in humans, but studies like these pave the way for our understanding of the complexities of the gut connection. Did you ever think your gut could have such an effect on your health? If you read my blog regularly, I sure hope so!

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Renew You Challenge

Let’s start this week off right!

Weekly challenge (I mean opportunity!) to help set you off on the right foot and in the right direction for bringing health to your week. You could even add it to your calendar.  Join us! 

Anxiety, or worry, is experienced by just about everyone at some point. Some people have anxiety disorders, which are more serious conditions, but it’s safe to say that most people experience at least occasional anxiety. That’s why a new study on omega-3s found in fish oil is so exciting. It’s the first study to look at the effects of fish oil on anxiety in a healthy population—meaning, in people who don’t already have an anxiety disorder. It’s already known that fish oil can be helpful for those people. But what about people who only experience anxiety here and there?

The researchers took a group of medical students and gave them omega-3 supplements for three months. The supplements contained 2,085 mg of EPA and 348 mg of DHA. Another group got a placebo. After three months, the group taking the fish oil showed a 20 percent reduction in anxiety scores and a 14 percent reduction in the production of the inflammatory marker interleukin-6 (IL-6) over the placebo group.

IL-6 is an inflammatory cytokine. Depression and anxiety are both known to involve the production of inflammatory cytokines. This is one of the gut-brain connections, actually, since the inflammation can originate in the gut. Omega-3s were able to reduce these inflammatory compounds, highlighting just one way they may be helping mood disorders like depression and anxiety.

This week, if you tend to get anxious about things, even if occasionally, and you’re not taking fish oil, you might want to reconsider. The studies on fish oil are hard to ignore.

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The gut-brain connection is an interesting one because it travels in two directions—from the brain to the gut and from the gut to the brain. For the longest time this connection was thought to only travel in one direction, from the brain to the gut, like when strong emotions trigger an upset stomach. But researchers now know that what happens in your gut has an effect on your brain.

One recent study at the Stanford University School of Medicine tried to elucidate this connection. According to one of the researchers, “Gastric irritation during the first few days of life may reset the brain into a permanently depressed state.” Genetic susceptibility also plays a role, of course, since not all stomach upsets will lead to depression, but this connection is interesting.

The gut is connected directly to the brain by the vagus nerve, and even has a nervous system of its own—the enteric nervous system. This connection between the gut and the brain allows for close communication. Many studies are finding that the gut has a major effect on the brain. I have blogged about it before. More than once.

The researchers used an animal model of functional dyspepsia, also known as indigestion, to determine that stomach irritation early in life can lead to depressed and anxious behaviors that last much longer than the indigestion itself. Their findings will lead to more studies to investigate how this gut brain connection works, and if new ways can be found to treat depression and anxiety in humans, based on the gut-brain link.

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The gut-brain connection is fascinating. It involves an intimate communication between the gut and the brain, and it goes in both directions—from the brain to the gut, and from the gut to the brain. I mean, isn’t it cool that what happens in your gut can affect your brain?

Yet another study looking at the gut-brain connection has found that gut bacteria are associated with anxiety. The researchers used an animal model to study this link, as it is easier to work out the details of these connections in animal models. Researchers found that antibiotic treatment altered the normal gut bacterial count, producing a change in behavior—the mice became anxious. They also experienced an increase in brain derived neurotrophic factor (BDNF), linked to anxiety and depression. When the antibiotics were stopped, behavior returned to normal.

To take this one step further, the researchers added gut bacteria from mice genetically prone to be passive, to mice prone to be more active and exploratory, and vice versa. They found that by giving the mice a different set of bacteria, the mice began to behave as the mice from which the bacteria were originally isolated. One of the researchers stated, “these results lay the foundation for investigating the therapeutic potential of probiotic bacteria and their products in the treatment of behavioral disorders, particularly those associated with gastrointestinal conditions such as irritable bowel syndrome.”

Like I said, the gut-brain connection is fascinating.  Did you know your gut had so much power over your health?

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The title of this article has been taken directly from the journal Gut Pathogens January 2011, and can be accessed for free at www.gutpathogens.com. This article tells the story of the gut connection. As we have been preaching for years, there is good evidence of a connection between gut bacteria and most (if not all) of the body organs, including the skin and brain.  What’s more, the above article presents much new, refined information, but the basic information is included from published references from 80-90 years ago!

Read, and be informed of the following concepts presented:

1.  The regular consumption of fat, sugar and simple carbs low in fiber, will decrease the beneficial bifidobacteria and other probiotic species in the colon and terminal small intestine (the end of the small intestine).

2.  Low  bifidobacteria allows increases of other bacteria that may promote colonic lining (epithelium) inflammation, with increased free radical damage and oxidative stress that leads to increased intestinal permeability (IP), or leaky gut.

3.  Increased IP leads to the passage (or translocation) of partially digested food particles, bacterial toxins, and other bacterial byproducts including fat (or lipids) from dead bacterial cell walls. 

4.  Bacterial cell wall lipids known as lipopolysaccarides (LPS), or also bacterial toxins, are easily measured in the blood, and are important indicators of how much overactivity will occur in the immune system.  Elevated LPS is very likely to occur after eating your favorite ice cream, or even too much bacon and eggs with toast and jelly (high fat, high sugar, and low fiber).

5.  Elevated blood levels of LPS cause the immune system to increase production of inflammatory markers (pro-inflammatory cytokines). These markers can cause many negative reactions, including decreased insulin receptor sensitivity, and thereby elevate blood sugar and insulin levels.

6.  Chronically elevated blood sugar and insulin promote increase in blood lipids, and  increase in inflammation which can contribute to acne, anxiety and depression, among other conditions.

Here is the good news,  a  high-fiber diet found in vegetables, whole grains, legumes, seeds and nuts, with some low glycemic fruits (especially berries) will promote high-normal levels of bifidobacteria. Taking prebiotic fibers was also shown in this article to increase bifidobacteria, and supplementing with bifidobacteria probiotics or fermented foods will definitely have overall beneficial effects on the body, including the skin and the brain. 

Leonard Smith, M.D.
Dr. Leonard Smith is a prominent Board-Certified, general, gastrointestinal and vascular surgeon who had a successful private practice for 25 years.  In addition to his active surgery practice, he also incorporated lifestyle, diet, supplementation, exercise, detoxification, and stress management into many of the therapies he would prescribe.  Many of his patients with cancer, cardiovascular disease, and other serious illnesses did so well under his treatment regimes that he began to devote most of his career to foundational health care and preventive medicine.   

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I like to call the proper balance of gut bacteria your “GPS”—your Gut Protection System. Your GPS works to: protect your intestinal lining; “crowd out” and neutralize the harmful bacteria; and influence the immune system so that it responds in the proper way to harmful invaders like bacteria, toxins, and even undigested food particles.

Your GPS might not be properly balanced—and you may not even know it. Sure, some people experience obvious digestive symptoms like gas and bloating, or heartburn, but some people don’t exhibit digestive symptoms, yet still have a gut imbalance. A malfunctioning GPS can have far-reaching health consequences. For example, many mood disorders, like depression and anxiety, are closely linked to gut health. Rheumatoid arthritis—how much further from the gut could you get?—is also known to be associated with gut imbalances. The list goes on and on. Read about it in my new book, The Road to Perfect Health, available exclusively through my PBS special of the same title. (Check your local PBS listings for show times.)

So, how does your GPS malfunction? Well, there are a number of ways. I’ll highlight some here:

Exposure to chemicals

• Certain medications (like antibiotics and acid-suppressing medications)
• Over processed and refined foods (I call them Dead Foods)
• Low stomach acid

In today’s world, it can be hard to avoid some of these triggers. That’s why it’s best to balance your gut with beneficial probiotic bacteria to get your GPS up and running. As I say: Balance your gut, heal your body.

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Exciting news! If you live in the greater Tampa Bay area, be sure watch me LIVE on WEDU-TV tonight from 8:00 to 10:00 p.m. for my NEW PBS special, The Road to Perfect Health.

A lot of folks don’t realize that a healthy body begins with a healthy gut. That’s because your digestive tract is where more than 80 percent of your body’s natural defenses are found, and it’s where trillions of bacteria live in a delicate balance to help you absorb nutrients, defend against toxins, and fight off illness and disease—not to mention help with bowel regularity!

But what may surprise you is that even things you wouldn’t normally associate with digestive health—everything from anxiety, joint aches and food sensitivities to fibromyalgia and even high cholesterol—they all start in the gut. That’s how important it is to keep your digestive system running smoothly.

Join me to learn the secret to balancing your gut and healing your body, beginning with the power of probiotics. Those are the beneficial bacteria in your intestines that help with healthy digestion and immune function, and they are the key to a strong GPS, or what I like to call your Gut Protection System. From there, I’ll give you the keys to rebuilding your health from the inside out and finally living the life you’ve always wanted. See you there!

If you don’t live in the Tampa Bay Area, The Road to Perfect Health is also airing nationwide right now through mid-December. Visit PBS for air times and station in your area.

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The day after Thanksgiving, my new PBS television special, The Road to Perfect Health, started airing nationwide and the response has been incredible. It was such a long but rewarding journey to bring all the elements of this new show together, and I’m so happy to finally be able to share the message of vibrant health with audiences all across America.

So many people in our lives are suffering—waking up every day with problems like poor digestion, fatigue, weight gain, anxiety, joint pain and so much more—but it doesn’t have to be that way. The secret to a healthy body begins with a healthy digestive system, and the information in The Road to Perfect Health will teach you all about what’s going on inside your gut and why it’s so important to keep your digestive system running smoothly.

Join me and together we’ll look at the trillions of good bacteria living inside your gut that help your body absorb nutrients, defend against toxins, fight off illness and disease, and yes, even help with problems like constipation, irritable bowel and other digestive issues. Those good-for-you bacteria are called probiotics, and they’re the key to a strong Gut Protection System—or GPS for short!

Just like the GPS in your car, all those good bacteria in your gut help keep you on the path to better health. But what happens when your GPS isn’t working right? You can get lost, and just like getting lost on the road, we sometimes lose our way on the road to better health and end up stuck in a rut of illness and poor digestion.

I hope you’ll tune in this month to learn the secret to rebuilding your health from the inside out. It’s time to balance your gut and heal your body! Check your local PBS station for dates and times.

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Folks, I can’t tell you how excited I am that in just a few days my new PBS special, The Road to Perfect Health, will begin airing nationwide. It’s been such a long but rewarding journey to bring all the elements of this new show together, and I’m so happy to finally be able to share the message of vibrant health with audiences all across America.

So many people in our lives are suffering—waking up every day with problems like poor digestion, fatigue, weight gain, anxiety, joint pain and so much more—but it doesn’t have to be that way. The secret to a healthy body begins with a healthy digestive system, and the information in The Road to Perfect Health will teach you all about what’s going on inside your gut and why it’s so important to keep your digestive system running smoothly.

Join me and together we’ll look at the trillions of good bacteria living inside your gut that help your body absorb nutrients, defend against toxins, fight off illness and disease, and yes, even help with problems like constipation, irritable bowel and other digestive issues. Those good-for-you bacteria are called probiotics, and they’re the key to a strong Gut Protection System—or GPS for short!

Just like the GPS in your car, all those good bacteria in your gut help keep you on the path to better health. But what happens when your GPS isn’t working right? You can get lost, and just like getting lost on the road, we sometimes lose our way on the road to better health and end up stuck in a rut of illness and poor digestion.

I hope you’ll tune this month and through December to learn the secret to rebuilding your health from the inside out. It’s time to balance your gut and heal your body!

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When your digestive system is out of balance, your health can suffer. And I’m not just talking about typical tummy issues like gas and bloating, constipation and irritable bowel, but all kinds of problems like fatigue, weight gain, skin problems and even anxiety. That’s right folks—everything is linked to your gut!

Want to know more? Join me on September 23^rd at Health Foods Unlimited in Centerville, Ohio for a free digestive health lecture. I’m going to be talking about the link between a properly functioning digestive system and a healthy body—including the natural supplements that are essential for helping you look and feel your best every day. Plus, if you’re one of the first 50 people to attend, you’ll receive a complimentary copy of my book Gut Solutions. See you there!

WHEN:

6:30-8:00 p.m. on Thursday, September 23^rd

WHERE:

Health Foods Unlimited

2250 Miamisburg Centerville Road

Centerville, OH 45459

RSVP: 937-433-5100

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